Small Cell Lung Cancer C-kit

Elimination Of Human Lung Cancer Stem Cells Through Targeting ...
Previously, we showed that chemotherapy of non–small cell lung cancer (NSCLC) cells lines can select for outgrowth of highly tumorigenic and metastatic CSCs. The high malignancy of lung CSCs shown that lung CSCs express c-kit receptors and produce ... Access Full Source

Analysis Of c-kit Expression In small cell lung cancer ...
Analysis of c-kit expression in small cell lung cancer: Prevalence and prognostic implications et al. Expression and mutational status of c-kit in small-cell lung cancer: prognostic relevance. Clin Cancer Res 2004;10:4101—8. ... Retrieve Content

Lung cancer And NormaL ceLL Lines - ATCC
E essenTiaLs o L ie s cience resea r c gLoaLL deLiered ™ Lung cancer and normaL ceLL Lines ATCC® No. Name Tissue Cell Type Disease Oganism Age Ethnicity Genes Expressed ... Fetch Full Source

C-Kit Signal Transduction And Involvement In cancer
C-Kit signal transduction and involvement in cancer Review Article Johan Lennartsson1, Olexandr Voytyuk2, Characterization of c-kit expression in small cell lung cancer: prognostic and therapeutic implications. Clin Cancer Res 9, 188-194. ... Access Doc

Targeted Molecules In Small Cell Lung Cancer
Targeted Molecules in Small Cell Lung Cancer Nevin Murray, Ravi Salgia, and Frank V. Fossella through CXCR4 and c-Kit in small cell lung cancer cells. Cancer Res 62:6304-6311, 2002 14. Krystal GW, Honsawek S, Kiewlich D, et al: Indolin- ... Doc Retrieval

Phase II Trial Of Imatinib Maintenance ... - Clinical Lung Cancer
Positive, Extensive-Stage Small-Cell Lung Cancer Bryan J. Schneider,1 Gregory P. Kalemkerian,2 Nithya Ramnath,2,3 Michael J. Kraut,4,5 Antoinette J. Wozniak,4 Francis P. Worden,2 Clinical Lung Cancer July 2010 Imatinib in c-Kit–Positive SCLC ... Read Document

Imatinib Mesylate Efficiently Achieves Therapeutic Intratumor ...
Imatinib Mesylate Efficiently Achieves Therapeutic Intratumor Concentrations in Vivo but Has Limited Activity in a Xenograft Model of Small Cell Lung Cancer ... Fetch Full Source

Seminar Small-cell lung cancer - The Lancet
Seminar Small-cell lung cancer is a distinct clinical and Moreover, mutations have been identified in the c-kit receptor of 10% of small-cell lung cancers.19 The tyrosine kinase inhibitor of c-kit, imatinib, has been ... Access This Document

New Targeted Therapies And Small-Cell Lung Cancer
In patients with c-kit expressing relapsed small-cell lung cancer: a CALGB and NCCTG study. Ann Oncol 2005; 16:1811-06. 20. small cell lung cancer (LS-SCLC): update of a phase II trial of the Minnie Pearl Cancer Research Network. ... Fetch Content

Detection Of Overexpressed And Phosphorylated Wild-Type Kit ...
Detection of Overexpressed and Phosphorylated Wild-Type Kit Receptor in Surgical Specimens of Small Cell Lung Cancer Elena Tamborini, 1Lorena Bonadiman, factor and the c-kit genes in small cell lung cancer. Oncogene 1991;6: 2291–6. 11. ... Visit Document

Therapeutic Efficacy Of C-Kit-Targeted Radioimmunotherapy ...
Therapeutic Efficacy of C-Kit-Targeted Radioimmunotherapy Using 90Y-Labeled Anti-C-Kit Antibodies in a Mouse Model of Small Cell Lung Cancer Chisato Yoshida1,2, Atsushi B. Tsuji1*, Hitomi Sudo1, Aya Sugyo1, Tatsuya Kikuchi3, Mitsuru Koizumi1, ... Doc Viewer

Mast cells Mediate Malignant Pleural Effusion Formation - YouTube
Mast cells mediate malignant pleural effusion formation. Treatment of mice with the c-KIT inhibitor imatinib mesylate limited effusion precipitation by mouse and human adenocarcinoma cells. Lung Cancer (Small Cell Lung Carcinoma and Non-Small Cell Lung Carcinoma) ... View Video

Targeted Therapies In small cell lung cancer: A Review
Targeted therapies in small cell lung cancer: a review Aidalena Z. Abidin, Marina C. Garassino, Raffaele Califano, Amelie Harle and Fiona Blackhall ... Access This Document

Accuracy Of c-KIT In lung cancer Prognosis; A Systematic ...
Accuracy of c-KIT in lung cancer prognosis; a systematic review protocol Asian Pac J Cancer Prev, 17 (2), 863-866 Introduction small cell lung cancer (NSCLC) (Ettinger et al., 2012; Kalemkerian et al., 2013). NSCLC that represents nearly ... View This Document

Caused By Activating Mutations Of Ing Imatinib Treatment. In ...
Development of c-Kit-expressing Small-Cell Lung Cancer in a Chronic Myeloid Leukemia Patient During Imatinib Treatment Imatinib inhibits the activities of ... Retrieve Full Source

CDKN1B - Wikipedia, The Free Encyclopedia
Similar correlations were observed in patients with non-small cell lung cancer, [31] those with colon, [31] ONCO: c-Kit; Flt3; Intracellular signaling P+Ps: Wnt signaling pathway: ONCO: Beta-catenin; TSP: APC; TGF beta signaling pathway: TSP: SMAD2; SMAD4; ... Read Article

Regulation Of Cellular Proliferation, Cytoskeletal Function ...
[CANCER RESEARCH 62, 6304–6311, November 1, 2002] Regulation of Cellular Proliferation, Cytoskeletal Function, and Signal Transduction through CXCR4 and c-Kit in Small Cell Lung Cancer Cells ... Fetch This Document

Original Paper Recombinant Human Stem Cell Factor Does Exert ...
Factor and the c-kit g&es in small-cell lung-cancer. Oncogene 1991, 6,2291-2296. Rygaard K, Nakamura T, Spang-Thomsen M. Expression of the proto-oncogenes c-met and c-kit and their ligands, hepatocyte growth factor/scatter ... Fetch Document

Small Cell Lung Cancer (SCLC)
Small Cell Lung Cancer (SCLC) Terry Moody, Ph.D. 9609 Medical Ctr. Dr. receptors on lung cancer cells causing Akt phosphorylation. Numerous lung cancer cell lines were isolated from biopsy specimens. ... Return Doc

Lack Of c-kit Exon 11 Activating Mutations In c-KIT/CD117 ...
Fig. 1. Representative photomicrographs of small-cell lung cancers (SCLC) (a–d) and gastrointestinal stromal tumours (GIST) (e–h). CD117/c-KIT ... Doc Viewer

Small Cell Lung Cancer - Penn State Hershey
SMALL CELL LUNG CANCER For personal use. The high coexpression of stem cell fac-tor/c-kit was shown to be relevant to SCLC biology with in small cell and small cell lung cancer with the same EGFR mutation. Lung Cancer. 2007 Dec;58(3):411-413. ... Doc Viewer

Lung Cancer Research: From Prevention To Cure (PDF)
C-Met, VEGF/R, c-kit/SCFR 2.Signal-transduction pathways Ras, raf, MAPK, MEK, ERK, protein kinase C, PI3K Non-Small Cell Lung Cancer lung cancer prevention, lung cancer research ... Access Doc